OBJECTIVES:  To assess the impact of chronic idiopathic constipation (CIC) on quality of life (QoL), work productivity, daily activities, and indirect costs in a sample of the US population. METHODS:  The BURDEN-CIC study utilized the Knowledge Network Panel™ to identify CIC patients, who participated in a 45-minute, 68-question, IRB-approved online survey. Healthcare professionals (HCPs) treating CIC patients participated in a 30-minute, 32-question online survey. RESULTS:  Over 1,100 CIC patients (mean age, 49 years; female, 70%; severe, 67%) completed the survey. Only 23% of patients felt “in control” of their symptoms, with 39% expressing “acceptance” that CIC was part of daily life. Of HCPs (n=331), 72% stated patients had high levels of frustration regarding CIC and were “stressed” (49%) or “fed up” (43%) regarding current treatments. Sixty percent of all CIC patients and 81% of severe CIC patients reported their symptoms bothersome and impacting QoL; daily activity participation was impacted 4 and 9 days/month, respectively. Most patients had used (62%) or were using (53%) OTC treatments for their CIC, with 16% currently using prescription treatment. Of current prescription therapy patients, 35% felt it was “effective,” but only 14% reported “good experience/satisfied