OBJECTIVES: To describe psoriasis (PsO) patients’ profile and to evaluate the impact of the disease on patients’ quality of life and work productivity in a real-life setting in Brazil. METHODS: This analysis used data from the GfK Disease Atlas multinational, retrospective, cross-sectional syndicated survey. The study sample consisted of Brazilian patients who have or have ever had moderate to severe PsO and who were receiving a prescribed treatment at the time of the survey. RESULTS: The overall sample included 497 Brazilian patients, 50% were male, mean age of 45.4, 81%. Of the total sample, 22% had moderate to severe psoriasis [Psoriasis Area Severity Index (PASI > 10 or Body Surface Area (BSA) ≥ 3 or Dermatology Life Quality Index (DLQI) > 10)] with mean disease duration of 7.7 years. Psoriatic arthritis (18%), anxiety or depression (18%) and cardiovascular diseases, obesity or type II diabetes (13%) were the most prevalent comorbidities among PsO patients. Despite treatment, 18% of patients reported currently disease exacerbating and 77% exacerbated in the past 12 months. At the moment of survey, 11% were being treated with biologic/biosimilar agents only, 4% with biologic and conventional systemic, 4% biologic and topical, 2% a combination of biologic, conventional systemic and topical agents. These patients had significant burden in terms of quality of life and work productivity, DLQI (mean score: 10.5); 12-Item Short-Form Health Survey (SF-12) - (Physical component summary: 47.4 and mental component summary: 41.6) and overall work impairment due to PsO: 42.2%, absenteeism (13.9%), presenteeism (35%)]. CONCLUSIONS: Results from this large real world survey revealed specific clinical aspects of psoriasis among Brazilian patients helping to address some medical needs in daily practice. Despite treatment, psoriasis places a substantial burden on patients’ life.