OBJECTIVES: This analysis aims to determine, in International Units (IU), the somatropin volume waste of presentations with 4 IU and 12 IU compared to 16 IU and 36 IU, when used for treatment of Turner Syndrome and for children treatment with disorders of growth due to deficiencies of growth hormone. METHODS: The amount waste per month was analyzed, in IU, from the dosage indicated in the Project of Clinical Protocol Guideline (PCDT) for Hypopituitarism of the Brazilian Health Ministry and a comparative analysis was done between presentations of 4 IU/ 12 IU (approved by Ministry) and of 16 IU/ 36 IU. RESULTS: The average loss per treatment/month (Turner Syndrome and children with growth disorders) are 18,36 IU, 12,08 IU, 0,38 IU and 2,01 IU presentations with 4IU,12IU, 16IU and 36IU respectively. CONCLUSIONS: Therefore, if the SUS adopt presentations of 16IU or 36IU, that could be reduce the losses in an average of 97,5% and 87% respectively in month/patient, minimize the treatment cost, optimize doses number and achieve more patients. Moreover, it is more advantageous because they take up less space for storage and for transportation.