OBJECTIVES: To compare the treatment cost of anti-TNF biologics indicated simultaneously for the treatment of rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) under the Brazilian public healthcare system (SUS) perspective. METHODS: In Brazil, four anti-TNF biologics are approved for the treatment of RA, AS and PsA: adalimumab (ADA), etanercept (ETA), infliximab (IFX), and golimumab (GOL). Published literature shows no difference in safety and efficacy among them; therefore, a cost-minimization analysis was performed as presented by Morais AD et al at ISPOR 18^th Annual Meeting. Yearly treatment costs were calculated for an average patient of 70 kg, according to dose and dosing intervals defined in products label. Prices were gathered from an official government website, as the four biologics are already reimbursed by SUS: ADA, ETA and IFX for the three indications, and GOL for RA only. Since IFX dose is weight-dependent, deterministic sensitivity analysis (DSA) was conducted to determine the impact of this parameter on results. RESULTS: GOL has the lowest cost of treatment across the biologics in all indications, at R$17,703 per patient per year. GOL treatment cost remains unchanged across indications or years of treatment, as loading dose is not required. For RA treatment, IFX has the second lowest cost of treatment at R$18,313/patient/year. For AS and PsA treatments, due to higher dosing of IFX, the average cost per patient is R$24,418, similar to the cost with ADA and ETA. Using DSA, cost of treatment with IFX for AS and PsA can reach up to R$30,522, assuming a patient weight of 100 kg. CONCLUSIONS: With the lowest cost of treatment, GOL is already available in SUS for RA treatment, and represents an important treatment option for patients with AS and PsA as well, with potential to reduce the cost of treatment by 27.5%.