OBJECTIVES: This study investigated the effect of BMI on quality of life, productivity, activity impairment, healthcare resource-utilisation, and associated costs.  METHODS: Results were from the 2011-2012 Brazil National Health and Wellness Survey (N=24,000), a nationally representative, online survey of respondents aged≥ 18 years. Analysis focused on normal weight (BMI≥18.5 & <25 kg/m2), overweight (BMI≥25 & <30 kg/m2), obese class (OC) I (BMI≥30 & <35 kg/m2), OC II (BMI≥35 & <40 kg/m2), and OC III (BMI≥40 kg/m2) respondents. Outcomes included quality of life (SF-36v2), health utilities (SF-6D), productivity loss (Work Productivity and Activity Impairment questionnaire) and resource utilisation (type/number of visits) in the past six months. Direct and indirect costs were estimated from public sources. Generalised linear models predicted outcomes as a function of BMI category, adjusting for covariates (e.g., age, gender, comorbidities).  RESULTS: Among 22,871 respondents, 46.4% were normal weight, 34.9% were overweight, 12.9% were OC I, 3.7% were OC II, and 2.0% were OC III. Adjusting for covariates, mental, physical component summary (normal weight: 51.8; overweight: 51.4; OC I: 50.3; OC II: 48.5; OC III: 46.0), and health utilities (normal weight: 0.73; overweight: 0.72; OC I: 0.71; OC II: 0.70; OC III: 0.67) decreased as BMI increased (OCs vs. normal, p<0.05). Amongst the employed (66.1%), impairment while working (normal weight: 15.5%; overweight: 15.6%; OC I: 16.9%; OC II: 18.2%; OC III: 22.4%, OCs vs. normal, p<0.05) increased as BMI increased. Normal weight (vs. OCs, p≤0.05) had lower activity impairment, fewer provider visits, and lower indirect costs (normal weight: R$333; overweight: R$338; OC I: R$385; OC II: R$395; OC III: R$458).  CONCLUSIONS: Over 50% of Brazilians are overweight or obese. Increase in BMI is associated with poorer outcomes and greater indirect costs. The distribution of BMI is similar to the 5 E.U. Finding suggest the need for additional weight-loss options.