OBJECTIVES: To assess the burden of hospitalizations due to Continuous Spikes and Waves During Slow-Wave Sleep (CSWS) in the Middle Atlantic region, using pooled national inpatient data from 2016 to 2020.

METHODS: The 2016-2020 National Inpatient Sample (NIS) datasets were pooled and analyzed for hospitalizations due to CSWS in the Middle Atlantic region. Six cohorts were created: (1) all hospitalizations, (2) hospitalizations above the 90th percentile by charges, (3) hospitalizations below the 90th percentile by charges, (4) hospitalizations above the 90th percentile by comorbidity score, (5) hospitalizations below the 90th percentile by comorbidity score, and (6) in-hospital deaths. Comorbidity rates were assessed using the Charlson Index, the Elixhauser Method, and broad ICD-10 categories. Severe infections were evaluated based on a previously reported list of infections.

RESULTS: From 2016 to 2020, there were an estimated 1,239 CSWS-related hospitalizations in the Middle Atlantic region. For the six cohorts, the mean ages were 36.72 (SD 21.96), 31.83 (SD 22.44), 37.25 (SD 21.9), 64.29 (SD 12.79), 34.67 (SD 21.12), and 40.5 (SD 29.15) years, respectively. The mean hospital length of stay (LOS) was 8.15 (SD 14.38), 29.04 (SD 27.89), 5.9 (SD 9.79), 18.47 (SD 18.47), 7.39 (SD 13.78), and 39.25 (SD 49.92) days, respectively. The mean total charges were $132,057 (SD 223,916), $642,301 (SD 429,752), $76,895 (SD 70,941), $221,087 (SD 241,528), $125,447 (SD 221,694), and $327,909 (SD 147,484), respectively. The comorbidity scores were 2.49 (SD 1.81), 2.79 (SD 2.02), 2.46 (SD 1.79), 7.12 (SD 1.17), 2.15 (SD 1.31), and 4 (SD 2.83), respectively. The rates of severe infections were 36%, 38%, 36%, 71%, 33%, and 50%, respectively.

CONCLUSIONS: Analyses of pooled five-year real-world hospital records of CSWS in the Middle Atlantic region show that these patients pose a significant clinical and economic burden.