INTRODUCTION: Colorectal cancer (CRC)5 was the second cause of mortality for every kind of malignant tumors in 2018 and promoves a real issue for Mexican health. CRC is the third worldwide most common cancer and it is projected to increase by 60% globally by 2030. Researching serotonin levels throughout time offers new data on just how wide reaching and long-lasting our serotonin effect really is.

OBJECTIVES: To describe colorectal cancer (CRC) mortality trends, years of life lost due to premature death (YLL), and excess mortality among Mexicans aged 30+ from 1998 to examine current trends through 2022.

METHODS: Longitudinal retrospective study through secondary data sources, such as mortality due to colorectal cancer (CRC), life expectancy and population projections (PEC 1998-2022). This consists in the INEGI death certificates with a malignant neoplasm of colon (ICD-10 codes C181-C189) or rectum (C19-C20). Population projections are taken from CONAPO. Annual percent change in mortality with Joinpoint regression focusing on rates and trends

RESULTS: From 1998-2022, Mexico recorded 135,101 CRC deaths in adults 30+. CRC deaths rose from 3,215 to 10,643, with the highest mortality rate at 17.0 per 100,000 in 2021. CRC mortality was higher in men, with the gap widening from 5 to 9 per 100,000. Annual mortality growth was 2.1% in men and 1.7% in women. Years of life lost increased significantly in both sexes.

CONCLUSIONS: From 1998-2022, CRC mortality in Mexico rose significantly, highlighting the need for improved prevention, early diagnosis, and treatment.