Abstract

Hundreds of combination therapies for cancer, infectious diseases, and metabolic, cardiovascular, autoimmune, neurological, and other disorders are currently licensed worldwide, and many others are soon to be launched. Combination therapy is intended as a combination of multiple drugs, each having a different mechanism of action and used separately (ie, different from fixed combinations). Multimodality treatment is a cornerstone of modern oncology treatment strategy because it targets key pathways in a characteristically synergistic or additive manner and potentially reduces drug resistance, thus, resulting in potentially higher efficacy than the monotherapy approach.