MODELLING THE LIKELY IMPACT OF THE OBESITY EPIDEMIC ON MORTALITY AND CAUSE OF DEATH IN OLDER ADULTS

Author(s)

Martin A, Martin C
Crystallise Ltd., London, UK

OBJECTIVES: The UK population is ageing, and the prevalence of obesity is increasing. To assess the likely impact of these two demographic trends, we used a stochastic all-cause, cause of death mortality model to determine changes in likely age of death associated with different body mass index (BMI) values in older adults. METHODS: The Sonata Vivo model adjusts population baseline mortality for known risk factors to calculate the mean age of death and most likely causes of death for an individual, and has been validated against long-term cohorts in the UK and USA. We used the model to calculate the difference in mean ages of death at BMIs of 27, 33, 37 and 42 compared with a BMI of 22 in men and women aged 55 to 90. We assumed all subjects were non-smokers with population average values for blood pressure, cholesterol and alcohol consumption. RESULTS: In adults aged 55 years at baseline, increasing BMI from 22 to 42 was associated with a decrease in mean age of death of 1.93 years in women and 1.89 years in men. The absolute difference in life expectancy across the BMI range decreased with increasing age at baseline, to 0.34 years in women and 0.15 years in men aged 90.  As expected, the model predicts a longer life expectancy in women than men at each age and BMI, but the relative difference between genders was smaller in those with a BMI of 42 than in those with a BMI of 22. Analysis by likely cause of death in 55 year old adults showed the main impact of obesity was on cardiovascular (CVD) and cancer deaths in women, and CVD and endocrine deaths in men. CONCLUSIONS: Obesity is likely to reduce life expectancy by up to 2 years in older adults in the UK, mainly from increased CVD mortality.

Conference/Value in Health Info

2015-11, ISPOR Europe 2015, Milan, Italy

Value in Health, Vol. 18, No. 7 (November 2015)

Code

PSY25

Topic

Clinical Outcomes

Topic Subcategory

Relating Intermediate to Long-term Outcomes

Disease

Diabetes/Endocrine/Metabolic Disorders

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