OBJECTIVES : On January 31,2020 WHO announced COVID19 as an Emergency Public Health of International Concern. The number of patients in Indonesia continues to grow. Antiviral in the Covid19 Drug Information Laboratory in Indonesia are Lopinavir/Ritonavir, Favipiravir, Remdemsivir, Oseltamivir, Chloroquine Phosphate and Hydroxychloroquine Phosphate. Therefore it’s necessary to know the basis and management of its use.

METHODS : An online systematic search was performed on articles published until March 30, 2020. We use search keywords that are tailored to the purpose of writing.

RESULTS : All six antivirals were used for the treatment of RNA virus. Chloroquine, Hidroxychloroquine and Remdesivir effectively control the SARS-CoV2 virus invitro. Lopinavir/Ritonavir, Hydroxychloroquine, Oseltamivir have been used clinically for the treatment of SARS-CoV2 virus. In 2020, there are 42 clinical trials of 6 antivirals. Guidance of the antivirus are from 3 China, Belgium and Indonesia. Its differences based on the patient's condition.

CONCLUSIONS : There is a lack of evidence of six antiviral effectiveness against the SARS-CoV2 virus. It have been used for other RNA viruses. It is supported by a safety profile. In a pandemic situation and the absence of a specific antivirus, the use of the six antiviruses can be done and can be useful.