OBJECTIVES: To report health-state utility values measured using the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) in patients diagnosed with reflux esophagitis (RE) and to explore how these values vary in relation to patient characteristics and other factors.

METHODS: A cross-sectional survey design was adopted. Patients diagnosed with RE were recruited from Shanghai RenJi Hospital of China. Face-to-face interviews were carried out from July 2018 to November 2019. Patients assessed their health status by using EQ-5D-5L and the gastroesophageal reflux disease questionnaire (GerdQ). The EQ-5D estimate was calculated on the basis of responses to five domains by using the Chinese population norms. Multiple regression analyses were adopted to predict the relationship between the EQ-5D estimate and patient characteristics.

RESULTS: 276 patients were included in the health utility analysis. The proportion of the disease duration ranged from 0.5 to 10 years was 40%, and the proportion of Los Angeles grade A/B according to an endoscopy‐based approach were 91%. The mean EQ-5D estimate in the full cohort was 0.86 ± 0.16 with a range from 0.15 to 1. The mean EQ-5D estimates in the Los Angeles grade A, B, C and D were 0.862, 0.844, 0.795 and 0.575, respectively. There were no responses of “extreme problem” for all five dimensions. The frequencies of “no problem” were over than 80% for mobility, self-care, usual activities, frequency of “slight problem” and “moderate problem” was about 66% for pain/discomfort, and frequency of “slight problem” to “severe problem” was about 80% for anxiety/depression. The log-logistic regression model showed that EQ-5D score was significant predictors of work-loss.

CONCLUSIONS: This study provides new insights into variations in health-state utility values from a single source that can be used to inform cost-effectiveness evaluations in patients with RE.