In the era of digital transformation, multiple trends are helping to shape our healthcare systems. Behavioral data enable patients to be interconnected with different health technologies. Patients are taking more active role in decision-making processes both as data providers and sometimes even as sole payers. The sociodemographic predictors of diseases reveal themselves in the process of data collection this allowing us to better understand that the treatment outcomes are sometimes dependent on multiple factors occurring outside of the healthcare system. Beyond machine learning and big data analysis, algorithms drive integrated disease management and personalized treatment pathways. Therefore, we can no longer simplify cost effectiveness evaluation to merely comparing health technology A versus health technology B. Instead, we also need to consider drawing comparisons to treatment pathway A versus treatment pathway B. In the digital era of integrated healthcare models, the question emerges as to whether we should consider moving into new methodological approaches accommodating multi-stakeholder interests? Do clinical outcomes reflect fully the value of digital health interventions? Do definitions of digital health interventions reflect their value? Do incremental cost-effectiveness ratios (ICERS) as we calculate them today support the digital revolution? Building on the conclusions of a recent systematic review, leaders of the ISPOR’s Digital Health Special Interest Group will discuss topics pertinent to the technology assessment of digital health innovations and engage the audience in an interactive debate. Participants will be encouraged to share their experiences, perspectives on to whether we should consider moving into new methodological approaches accommodating multi-stakeholder interests and provide insights for additional methodologies and considerations. The feedback collected will provide opportunities to define further research questions and examine recommendations for the next steps with a new focus on the challenges of economic evaluation of digital health solutions.