Next-generation sequencing, targeted cancer products, even commercial companies will provide genetic profiles for consumers. The availability of genomic data and health information through the digital technologies has the potential to greatly benefit health. However, how do we optimize the integration of this information into clinical practice? Are we inadvertently creating disparities and inequities in health care? We have four presenters that will discuss these questions from a practical standpoint, each from a different perspective including a community-based, safety net hospital system with a large rural population, a market access consultant perspective, and a patient perspective. Additionally, the panel will discuss recent research on patient preferences. During the meeting, attendees will have the opportunity to share their perspectives and challenges in translating genomic information into clinical practice.