Cost-Effectiveness of Avelumab as First-Line Maintenance Treatment for Locally Advanced or Metastatic Urothelial Carcinoma in Finland
Author(s)
Karttunen E1, Jaaskelainen S2, Hervonen P3, Chang J4, Kearney M5
1Merck OY, Espoo, Finland, an affiliate of Merck KGaA, Espoo, 18, Finland, 2Merck OY, Espoo, Finland, an affiliate of Merck KGaA, Espoo, Finland, 3Helsinki University Hospital, Helsinki, Finland, 4Pfizer, New York, NY, USA, 5the healthcare business of Merck KGaA, Darmstadt, Germany
OBJECTIVES: Avelumab is a fully human IgG1 antibody that targets PD-L1. Avelumab is approved in Finland as monotherapy for first-line maintenance treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has not progressed during platinum-based chemotherapy. This study aimed to assess the cost-effectiveness of avelumab + best supportive care (BSC) versus BSC alone in the aforementioned indication in the Finnish healthcare setting. METHODS: Using a Finnish healthcare perspective, a cost-utility analysis was conducted by building a 3-state partitioned survival model, which was used to estimate costs, effects, and an incremental cost-effectiveness ratio (ICER) during a base case time horizon of 25 years. Efficacy, safety, and utility parameters were derived from the phase 3 study JAVELIN Bladder 100, which was the primary data source, together with Finnish expert input and cost literature. Clinical study results were extrapolated with parametric survival curves, including spline-based models for progression-free survival. Both costs (2020 euros) and effects were discounted at a 3% annual discount rate. In addition, scenario analyses and a probabilistic sensitivity analysis were conducted to assess the effect and magnitude of uncertainty. RESULTS: In the base case analysis, avelumab + BSC achieved 1.00 additional life-year (3.94 vs 2.95) and 0.63 (2.44 vs 1.82) quality-adjusted life-years (QALYs) compared with BSC alone. The ICER was <3 times the GDP per capita per QALY gained. Sensitivity analyses show that the relative dose intensity of avelumab, along with parameters relating to subsequent treatment lines, have a significant impact on cost-effectiveness. CONCLUSIONS: Avelumab provides a significant clinical improvement in a patient population affected by a severe form of cancer that usually carries a relatively poor prognosis. In addition, avelumab is a potentially cost-effective treatment option compared to BSC alone, in patients eligible for first-line maintenance treatment of locally advanced or metastatic urothelial cancer in the Finnish healthcare setting.
Conference/Value in Health Info
2021-11, ISPOR Europe 2021, Copenhagen, Denmark
Value in Health, Volume 24, Issue 12, S2 (December 2021)
Code
POSC66
Topic
Clinical Outcomes, Economic Evaluation, Patient-Centered Research
Topic Subcategory
Clinical Outcomes Assessment, Cost-comparison, Effectiveness, Utility, Benefit Analysis, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Oncology, Urinary/Kidney Disorders
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