Helen Knight is a Programme Director at the National Institute for Health and Care Excellence (NICE) responsible for the health technology assessment methods used to produce national guidance. With an academic background in biochemistry and health economics, she spent 6 years working as a health economist for a health outcomes consultancy before joining NICE in the Technology Appraisal Programme in 2007. She has extensive experience of health technology assessment over a wide range of technologies and disease areas. As Programme Director, she is responsible for the methods for developing and delivering of guidance within the Centre for Health Technology Evaluation.