Harlan Krumholz is a cardiologist, the Director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation (CORE) and the Harold H. Hines, Jr. Professor of Medicine at Yale University. He is a leading expert in the science to evaluate and improve the quality and efficiency of care, reduce disparities, improve integrity in medical research, and avoid wasteful practices. His team has led successful national and international quality improvement initiatives, architected national quality measures and measurement strategies in partnership with CMS, promoted patient-centric approaches to research and care, created strategies and tools to enable open science and advance scientific integrity, and advanced regulatory science in partnership with the FDA. Dr. Krumholz is a co-founder of HugoHealth, a patient-centric platform to engage people as partners in research and clinical care, facilitating interoperability and the secure, permission-based movement of digital health data. He is a co-founder of medRxiv, a preprint server for clinical research. Dr. Krumholz is a member of the National Academy of Medicine and was named one of the top-cited scientists, with an h-index of almost 200. He received degrees from Yale College, Harvard Medical School and the Harvard School of Public Health.