Building Trust in Real-World Evidence: The Role of Study Registration

Real-world evidence on treatment outcomes can be an important aspect of the evidence basis for decision making if it is seen as credible. For real-world studies that are meant to test hypotheses about comparative-effectiveness or safety, a key aspect of credibility is that they are conducted transparently with tests that follow a prespecified analytic protocol. Preregistration of such study protocols on a public website would help build trust that their results can be used for decision-making purposes.

This Summit will be a forum for discussion of the work of the Real-World Transparency Partnership, led by ISPOR, ISPE, Duke-Margolis, and the National Pharmaceutical Council, and involving a number of other organizations and stakeholders. It will focus on the key elements needed for the creation of a common registration site for these real-world studies that will be oriented for regular use by researchers and seen as a credible registry by decision makers. The work already completed in this effort will be presented and the future steps envisioned will be discussed with Summit attendees.

Join us at this Summit to learn more about this initiative and help shape its work to come!


Click here to access the white paper and answer the call for comments.

Real World Transparency Partnership